Defrost the Shrimp - If using frozen shrimp, place them in a colander and run cold water until no longer icy, about 3 minutes. Alternatively, set them in a bowl and fill with room-temperature water until defrosted. Thoroughly drain and pat dry using paper towels.
Add the Cajun Seasoning - In a medium bowl, combine shrimp, 1 tablespoon olive oil, paprika, salt, garlic powder, onion powder, black pepper, oregano, cayenne pepper, and red pepper flakes.
Saute the Vegetables - Heat a 12-inch skillet or cast iron pan over medium heat. Add 1 tablespoon olive oil. Once hot, add the garlic and saute until fragrant, 30 seconds. Add the onion and saute for 90 seconds. Add the red and green bell peppers and saute for 1 minute. Transfer vegetables to a clean bowl.
Cook the Shrimp - Melt the butter in the pan. Add the shrimp in a single layer. Cook without moving until they turn pinkish on the bottom and start to curl, about 2 minutes. Flip and cook until curled into a loose “C” shape, about 1 minute.
Combine Ingredients - Add the sauteed vegetables and stir to combine for 1 minute, then turn off the heat. Transfer to a serving platter. Garnish with parsley and serve with lemon wedges.
Notes
Make it Spicier: Use ¼ teaspoon cayenne pepper or ¼ teaspoon red pepper flakes.